Refissa Tretinoin Cream is a fragrance free, emollient treatment that contains 0.05% new-generation tretinoin, a derivative of vitamin A that works deep at the skin’s cellular level. Obagi Refissa Tretinoin Cream is approved by the FDA and is clinically proven to be effective for facial wrinkles, rough skin, as well as irregular pigmentation. Diminishes fine facial wrinkles. It fades irregular pigmentation due to sun damage and smoothes the skin so it’s softer to the touch. It is the only 0.05% strong prescription tretinoin cream that’s fragrance-free with a moisturizing, emollient base. You must consult skin care professional before using this product.